Flyer

Journal of Neurology and Neuroscience

  • ISSN: 2171-6625
  • Journal h-index: 15
  • Journal CiteScore: 2.13
  • Journal Impact Factor: 1.45
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
20+ Million Readerbase
Indexed In
  • Open J Gate
  • Genamics JournalSeek
  • The Global Impact Factor (GIF)
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Proquest Summons
  • Scientific Journal Impact Factor (SJIF)
  • Euro Pub
  • Google Scholar
  • Secret Search Engine Labs
Share This Page
Recommended Webinars & Conferences

36th European Neurology Congress 2023

Amsterdam, Netherlands Antilles

Abstract

A case report of lethal cerebral encephalocele and antiphospholipid antibiotic response following SARS-CoV-2 vaccination

Mattia Iacobaeus*

Acute hemorrhagic encephalomyelitis (AHEM) is a relatively uncommon hyperacute form of acute disseminated encephalomyelitis (ADEM). The disease is distinguished by fulminant inflammation and demyelination of the brain and spinal cord, and it is frequently preceded by an infection or vaccination. A 53-year-old man with rheumatoid arthritis and ongoing methotrexate and etanercept treatment developed fatal AHEM after receiving the second dose of the COVID-19 vaccine. Multiorgan thromboembolic disease complicated the disease course, as did the presence of high/moderate levels of cardiolipin IgG antibodies and anti-beta-2 glycoprotein 1 IgG antibodies, indicating a possible antiphospholipid syndrome. Immunosuppressive therapy failed to improve the situation. Comprehensive clinical, neuroimaging, and neuropathological findings are included in the report. The case focuses on diagnostic challenges in a patient who has multiple diagnoses. preceding risk factors, such as autoimmune disease, immunotherapy, and vaccination, may have pathophysiological implications. Although evidence cannot be established, the temporal association with the COVID-19 vaccination may suggest possible causality. Reporting potential adverse events following COVID-19 vaccination is critical for identifying at-risk populations and achieving pandemic control.

Published Date: 2022-11-02; Received Date: 2022-10-03