Acta Rheumatologica

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A Clinical Case of A Patient with Moschkovitz Syndrome and Leukocytoclastic Vasculitis in the Childhood and Demyelinating Polyradiculoneuropathy Presenting with Transverse Myelitis in the Elderly

Desislava Kalinova,  Alexander Kopchev, Rasho Rashkov

Transverse myelitis is one of the causes of acute transverse myelopathy, as three main categories are described in the differential diagnosis of transverse myelitis - demyelination (multiple sclerosis, neuromyelitis optica), nfections and some autoimmune connective tissue disorders (systemic lupus erythematodes, vasculitis). We present a clinical case of a 33-year old patient with acute inflammatory demyelinating polyradiculoneuropathy (Guillaine-Barre syndrome) presenting with Landry's acute flaccid (ascending) paralysis and transverse myelitis in the elderly and medical history for Moschkovitz syndrome (thrombotic thrombocytopenic purpura, TTP syndrome) and leukocytoclastic vasculitis when he was 12 years old. The patient was treated with corticosteroids, intravenous immunoglobulin and symptomatic treatment, as after 9 months of therapy the patient regained muscle strenght in all four limbs.