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Molecular Enzymology and Drug Targets

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Abstract

A Note on Purine Analogues with Electronic Absorption in the Visible Region.

Andrzej Rykowski

The absorption spectrum of some 5-substituted derivatives was found to extend to the visible region. These compounds were found to inhibit some enzymes of purine metabolism, like xanthine oxidase or bacterial purine-nucleoside phosphorylase with Ki values in the 10-3 –10-5 M range.

Keywords

Thiazine; Purine analogues; Enzyme inhibitors; Spectroscopic probes.

Published Date: 2022-05-30; Received Date: 2022-05-02