MD. MASUDUR RAHMAN, MD. SAIFUL ISLAM, MD. SEKENDAR ALI, MD. RAFIKUL ISLAM, MD. ZAKIR HOSSAIN
The research work was designed to investigate the antidiabetic activity of the methanol extract of flowers of Tabernaemontana divaricata on alloxan indueced diabetic mouse model. The extract was given intraperitonially at a single dose of 200 mg/kg and 300 mg/kg body weight and the blood glucose levels were measured at 0, 1, 3, 5, 10 and 24 hours of the study period. The antihyperglycemic effect of the extract was compared with metformin, a standard drug. The dose of 300 mg/kg was found to be more effective dose to reduce maximum blood glucose level at 10th hour of the treatment period from 14.15± 0.42 to 8.81± 0.27 mg/dl whereas maximum result was obtained for metformin at the same time from 14.04±0.36 to 6.13±0.19 mg/dl. The extract was also subjected to Brine shrimp lethality bioassay. LC50 value of the extract was 84.03 μg/ml and for vincristin sulphate, it was 10.58 μg/ml. So, the present results suggest that Tabernaemontana divaricata possess antidiabetic activity in mice with alloxan induced diabetes and low cytotoxicity that may provide new molecules for the treatment of diabetes
