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International Journal of Drug Development and Research

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Abstract

Antiproliferative effect of Ocimum sanctum Against Benzo[A]pyrene Induced Lung Tumours in Rats

Arun Kumar*, Jyotsna Sethi and Chandrajeet Kumar

The disease of lung has increased many folds in the recent times. Unfortunately, the lung cancer disease cases have also been reported many times. Although smoking tobacco products are thought to be the causative agents. But the environmental pollution has elevated the disease risk. Among the common carcinogens, Benzo [A]pyrene is one of the known carcinogens which is directly responsible for the cause of the disease. It is a member of polycyclic aromatic hydrocarbon group and is usually generated during the partial burning of organic matter. Benzo (a) pyrene has been shown to inflict damage on the lungs as well as liver. Thus, the present study has been aimed to study the anticancer activity of Ocimum sanctum leaf extract on Benzo [A]pyrene induced lung cancer in rats. Male Charles Foster rats, 6 weeks old weighing around (150-180 g) were used for the study and were induced Benzo[A] pyrene (25 mg/Kg dissolved in Olive oil) orally in two intervals (1st day and 14th day) and were left for 3 months. After 3 months, there were development of lung tumors, which were histopathologically confirmed. Thereafter, Ocimum sanctum leaf extract at the dose of 200mg/Kg body weight was administered to the rats for 5 weeks. After the treatment there was significant reduction in the lung tumor size in the studied rats. All the parameters were studied and their data were analyzed. The haematological parameters, the biochemical parameters and the histopathologically parameters were also correlated for the efficacy of the drug.

Through the entire study, it can be concluded that, leaf extract of Ocimum sanctum possesses anti-proliferative effect against Benzo [A]pyrene induced lung cancer. This drug after various trials can be recommended as therapeutic drug for lung cancer disease in the future.

Keywords

Benzo[A]pyrene induced lung model; Tumor volume; Biochemical parameters study; Histopathological study; Leaf extract of Ocimum sanctum; Anti-proliferative activity; Novel drug discovery

Published Date: 2023-07-31; Received Date: 2023-07-03