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Association between Ambient Temperature and Blood Biomarker of Systemic Inflammationin (C-reactive protien) in Diabetes Patients

Morteza A Khafaie, Chittaranjan S Yajnik, Mehdi Mojadam, Behzad Khafaie, Sundeep S Salvi, Ajay Ojha, Sharad S Gore

Background: Climatic conditions, especially changes in temperature are associated with cardiovascular (CV) events but underlying mechanisms are not well understood. We investigated association between air temperature and C-reactive protein (CRP), in type 2 diabetes patients.

Methods: The subjects were resident of Pune city and suburbs (n=1700). The relationships between air temperature at lag 0-5 and different averaging time periods (3 and 7 days) and CRP concentration were analyzed using robust regression models. Sensitivity of our result to possible influence of additional adjustments for season, and air pollutants variable including PM10, NOx, and SO2 were investigated.

Result: Mean daily air temperature during study period varied between 15°C to 34°C. A 5°C decrease in the air temperature was associated with significant increase of 15.26% (95% CI=4.42 to 24.88) in geometric mean of CRP concentration with a lag of 1-day.

Conclusion: This study suggests that decrease in temperature is associated with change in CRP which is important risk factor for CV. We need to investigate physiological and environmental mediators of this association to help improve CV risk.