The blood-brain barrier (BBB) is a specialized system of blood vessels that controls the exchange of substances between the blood and the brain. It is composed of tightly packed endothelial cells, surrounded by astrocytes and pericytes, which create a selective barrier that restricts the passage of molecules based on their size, polarity, and charge. The BBB serves as a protective barrier, preventing the entry of harmful substances while allowing essential nutrients to pass through. However, it can also limit the delivery of therapeutic drugs to the brain, posing a challenge for the treatment of neurological disorders. The BBB is a complex and fascinating system that continues to be the subject of ongoing research in neuroscience and pharmacology.
Published Date: 2023-01-31; Received Date: 2022-12-31