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Bone Mineral Density Assessment in Chronic Liver Disease

Prem kumar K, Krishnasamy Narayanasamy, Janifer Jasmine J, Chezhian A and Senthil Kumar R

Aim: The present study was aimed at estimating the prevalence of osteoporosis, symptoms, etiology, factors influencing the osteoporosis in patients with liver complications and to study the association of osteoporosis and severity of liver dysfunction and impact of osteoporosis on quality of life.

Methods: 90 eligible patients tested in Rajiv Gandhi Government General Hospital. Patient’s samples were collected, tested and results recorded.

Results: Out of 90 patients (M-84.4%, F-15.6%) and as age progressed, osteopenia and osteoporosis found than the normal patients. Higher percentage of patients had Fatigue symptoms. Common etiology was HBV. As the Child-Pugh-Turcotte (CTP) scoring was increased from A to C the numbers of patients were increased from normal to osteopenia followed by osteoporosis. Statistical significance was found between Normal and Low Bone Marrow Density (BMD) with Model for end-stage liver disease (MELD), Vitamin-D, Para-thyroid hormone and Duration of diseases. Statistical significant found between Normal and Low BMD in the elevation biological markers like T. bilirubin, AST, ALT, SAP (females) and Albumin.

Conclusion: Among the liver diseases patients ¾ of them were with Low BMD. Linear progression of low BMD was found with increased age. With the symptom also we can detect low BMD in liver diseases patients. As the CTP increased low BMD was observed. Alcoholic liver disease had highest proportion of osteoporosis. Routine testing of vitamin D in HBV patients, higher MELD and increased duration of liver diseases will guide us for better and early diagnosis of low BMD among the liver diseases population.