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Journal of Neurology and Neuroscience

  • ISSN: 2171-6625
  • Journal h-index: 15
  • Journal CiteScore: 2.13
  • Journal Impact Factor: 1.45
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
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Abstract

Bradykinic-Mediated Angioedema Related to Alteplase Successfully Treated by Frozen Fresh Plasma (FFP) in Saudi Arabia: A First Case Report and Literature Review

Narjes M*, Sana K,  Neveen F, Bashir I, Hani K, Hassen M and Ahmed M

Angioedema can be a life-threatening complication after thrombolytic therapy (tPA). The incidence is 1-5%, the risk of developing bradykinin-mediated angioedema is multiplied by 6 in patient on angiotensin converting enzyme inhibitor. Most therapeutic options are ineffective or expensive and not available. FFP is known as effective treatment for bradykinin-mediate angioedema since 1969 but never reported in case of angioedema tPA induced. We report a case of 60year old patient with history of hypertension treated with angiotensin converting enzyme inhibitor, who developing severe bradykinin-mediates angioedema 10 min after the end of thrombolytic therapy. The patient was treated successfully with FFP. We are reporting this case to increase the awareness of physicians and to widen their therapeutic options when encountering this clinically significant condition.