Molecular Enzymology and Drug Targets

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Caspases and Apoptosis

Payam Behzadi, Reza Ranjbar

Apoptosis is a natural guard against disorders and diseases which is performed throughout programmed cell death. The process of apoptosis involves a diversity of enzymatic mechanisms. Because of the important role for caspases, the main aim of this review is to discuss about related caspases. In association with the present article, several review and original were searched via Google Scholar search engine and PubMed database. Simultaneously, the knowledge of the authors was used to prepare a collection of applied and invaluable data for writing the paper. There are a wide range of caspases which are involved in apoptosis processes. But in accordance with functional aspect, there are three categories of caspases including apoptosis initiators, apoptosis executioners and inflammation mediators. The presence, lack and level of caspase enzymes show the type of disease and infection. So, detection and identification of the enzymes are valuable for diagnosis and treatment. In conclusion, caspase enzymes have a key role in apoptotic processes and clinical diagnosis and treatment.