Mfouth Kemajou*
The persistent and varied nature of symptoms observed in individuals with long COVID has spurred an urgent need for a comprehensive understanding of this complex syndrome. This study delves into the heterogeneous landscape of long COVID by employing sophisticated cluster analysis techniques on a cohort of Belgian patients. The analysis reveals the existence of two distinct subtypes, each characterized by unique clinical manifestations, demographic profiles, and potential underlying factors. The first subtype showcases a prolonged predominance of respiratory symptoms, with a notable prevalence of lingering respiratory distress. In contrast, the second subtype presents a more diverse array of persistent symptoms, spanning neurological and cardiovascular domains. This manuscript explores the implications of these findings for clinical management, highlighting the necessity for tailored therapeutic interventions and targeted strategies to address the varied clinical presentations within the long COVID spectrum. Additionally, we discuss the potential molecular and immunological underpinnings of these subtypes, shedding light on the pathophysiological mechanisms contributing to the prolonged and diverse symptomatology observed in long COVID patients. This study contributes significantly to the evolving understanding of long COVID and emphasizes the importance of a nuanced approach to patient care.
Published Date: 2024-01-24; Received Date: 2023-11-05
