Flyer

International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 49
  • Journal CiteScore: 11.20
  • Journal Impact Factor: 8.24
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Publons
  • MIAR
  • University Grants Commission
  • Euro Pub
  • Google Scholar
  • J-Gate
  • SHERPA ROMEO
  • Secret Search Engine Labs
  • ResearchGate
  • International Committee of Medical Journal Editors (ICMJE)
Share This Page

Abstract

CNS STIMULATION EFFECT OF SEMISYNTHETIC ADDUCT OF CAFFEINE WITH SCHIFF�??S BASE OF PYRAZOLONE AND PYRAZOLO-PYRIMIDINE NUCLEUS

DIPESHKUMAR A. CHAUDHARI* AND DHRUBO JYOTI SEN

The CNS stimulation study has been performed on the two semisynthetic adducts of caffeine with Schiff?s base of pyrazolone and pyrazolone-pyrimidine nucleus. All the reference drugs and test compounds showed positive effect on CNS stimulation. The conclusion has been drawn from the fact that CNS stimulation effect for pentylene tetrazole is higher than caffeine, compound-I (pyrazolone ring) is less active than compound-II as the compound-II (pyrazolo-pyrimidine ring) is fused ring heterocyclic compound and the synergistic action with caffeine with compound-I having less activity than the compound-II but in case of leptazol (pentylene tetrazole), the synergistic activity of the two test compounds are equal but less than leptazol itself. The azole group is present in both caffeine and in leptazol but in fused ring heterocyclic chromophore and the same ring has been implemented in the two test compounds which have been semisynthesized by formation of Schiff?s base of caffeine to keep the similar bioisosteric nature. So, the components that have been semisynthesized showed the specific CNS stimulation activity.