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International Journal of Drug Development and Research

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Abstract

COMPLEXATION, CHARACTERIZATION, AND TOXICOLOGY STUDIES OF THE CRUDE EXTRACT OF ANACARDIUM OCCIDENTALE LEAVES AND ITS COPPER (II) COMPLEX

Akinola Dolapo Esther, Oladipo Adelaide Mary, Ajao Folasade Omobolanle* and Iyedupe Marcus Olaoye

Aim and objective: The search for effective therapy for diabetes mellitus is still unattainable. This study investigated anti-diabetic effect of Anacardium Occidentale Ethanolic leaves extract and Ethanolic leaves extract complex copper (II) in alloxan-induced diabetic rats.

Method: Fifty six matured male Wistar rats (200-250g) were used. Alloxan monohydrate (65 mg/kgb.wt) was singly injected intraperitoneally to induced diabetes. The animals were randomly alienated into 7groups, 8rats/group. Group I: normal control; Group II: diabetic; Group III & IV: diabetic rats + 400 mg/kgb.wt and 600 mg/kgb.wt A. Occidentale Ethanolic crude leaves extract; Group V and VI: diabetic rats + 400 mg/ kgb.wt and 600 mg/kgb.wt Ethanolic leaves extract complex copper (II); Group VII: diabetic rats + 500 mg/kgb.wt metformin for 15 days. Body weight and fasting blood glucose (FBG) were recorded at day 0, 5th, 10th, and 15th of the experiment. The animals were sacrificed at the end of the experiment and fasting blood samples were collected for biochemical parameters assay.

Results: Malondialdehyde (MDA), FBG, lipid profile, hepatic and kidneys function biomarkers levels were significantly (p<0.05) increased in the diabetic rats while the body weight and antioxidant activities were significantly (p<0.05) reduced. Administrations of A. Occidentale Ethanolic leaves extract, Ethanolic leaves extract complex copper (II) and metformin significantly (p<0.05) diminished the FBG, MDA, lipid profile, hepatic and kidney function biomarkers levels and elevated the body weight and antioxidant activities.

Conclusion: The Ethanolic leaves extract complex copper (II) possesses more anti-diabetic efficacies. This could be explored as effective complementary therapy for diabetes mellitus.

Keywords

A. Occidentale leaves; Diabetes mellitus; Dyslipidemia; Leaves extract complex copper (II); Oxidative stress

Published Date: 2023-06-30; Received Date: 2023-06-01