Journal of Neurology and Neuroscience

  • ISSN: 2171-6625
  • Journal h-index: 18
  • Journal CiteScore: 4.35
  • Journal Impact Factor: 3.75
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Open J Gate
  • Genamics JournalSeek
  • The Global Impact Factor (GIF)
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Proquest Summons
  • Scientific Journal Impact Factor (SJIF)
  • Euro Pub
  • Google Scholar
  • Secret Search Engine Labs
Share This Page


Comprehending the Blood-Brain-Barrier, Vital Constraints and Recent Updates for CNS Therapeutics

Gurpreet Singha*, Palak Jhamba, Mehak Bhata, Sankar Ramakrishnan, Kaisar Razac and Amita Sarwala

he Blood-Brain Barrier (BBB) acts as a hindrance to the transport of potential therapeutic agents in the brain; hence it serves as a major limiting factor to treat pharmacological dysfunction of the central nervous system (CNS). In a healthy brain, the BBB act as an essential barrier for protecting normal brain functions by preventing the transportation of foreign substances from the systemic circulation into the brain.

Area covered

This review gives us complete knowledge of the anatomical structure of the BBB and mechanisms involved in drug transport. It highlights the major aspects to be considered for the effective brain delivery of the drugs. It has also covered different types of barriers that obstruct the entry of therapeutic agents as well as the current strategies and approaches that facilitate penetration across the barrier for enhanced drug delivery to the CNS.

Expert opinion

There is a need for an in-depth understanding of the physiochemical activity of the carriers used, pharmacokinetic properties of the therapeutics required to be delivered, as well as the anatomical and biological factors which have an immense influence on the delivery of the drugs to the brain.

Published Date: 2021-10-12; Received Date: 2020-07-05