International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 49
  • Journal CiteScore: 11.20
  • Journal Impact Factor: 8.24
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Publons
  • MIAR
  • University Grants Commission
  • Euro Pub
  • Google Scholar
  • J-Gate
  • Secret Search Engine Labs
  • ResearchGate
  • International Committee of Medical Journal Editors (ICMJE)
Share This Page


Development and Optimization of Cefaclor Gastroretentive Osmotic control release Tablets

Prasad Garrepally, Gonugunta Chandra Sekhara Rao

The purpose of this present research work was to development and optimization of different formulations of osmotic control gastroretentive tablets containing Cefaclor. The cefaclor osmotic control gastroretentive tablets was formulated by 3 step process involve core tablet, coating and pore forming. Core tablets were formulated by using different polymers HPMC, polyox and sodium CMC alone and in combination. Initially drug excipients interactions were carried by using FTIR spectra; results showed that there was no interaction. Twelve different formulations of cefaclor osmotic control gastroretentive were prepared and characterized for flow properties and physical properties. Results of these parameters were within the Pharmacopoeial limits. Floating behaviour of all formulations was reported to be less than 100sec of floating lag time and greater than 12hr of duration of floating. F 7 formulation was selected as a optimised based on in vitro drug release studies. It showed the drug release patters similar to that of theoretical release. In vitro dissolution data of all formulation were fit into different kinetic models to know the mechanism of drug release; results revealed that the optimised F 7 formulation gave perfect zero order type of drug transport. Finally, stability studies were performed for optimised formulation and result revealed no significant difference between before and after storage for selected formula.