Flyer

International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 49
  • Journal CiteScore: 11.20
  • Journal Impact Factor: 8.24
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Publons
  • MIAR
  • University Grants Commission
  • Euro Pub
  • Google Scholar
  • J-Gate
  • SHERPA ROMEO
  • Secret Search Engine Labs
  • ResearchGate
  • International Committee of Medical Journal Editors (ICMJE)
Share This Page

Abstract

EFFECT OF INDIGOFERA ASPALATHOIDES LEAF EXTRACT ON HEPATIC XENOBIOTIC ENZYMES ACTIVITY IN HAMSTER WITH DMBA INDUCED ORAL CANCER

Philips Abraham, V Arul a, Sachu Philip b, B Padmakeerthiga a, Nirmal R Madhavan c ,S Sethupathy

Xenobiotic metabolizing enzymes, which activate procarcinogen in to ultimate carcinogen are known to play a major role in the carcinogenic effect of Poly Aromatic Hydrocarbons .Influence on Hepatic Xenobiotic enzymes and Chemopreventive effect of ethanolic extract of Indigofera aspalathoides(EIA) was tested on DMBA induced hamster buccal pouch carcinoma model. It has been observed that hamster treated with EIA showed a significantly low level of hepatic phase I enzyme and high level of Phase II enzymes, which might be the reason for its chemopreventive effect