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Efficacy of Tamoxifen for Treating Idiopathic Retroperitoneal Fibrosis

Alberto López-Serrano, Mauricio Mínguez Vega, M Del Pilar Bernabeu and JM Segui Ripoll

The term retroperitoneal fibrosis (or Ormond’s disease) encompasses a group of diseases characterized by fibrosis and inflammation of the tissue in the retroperitoneal space, which may surround abdominal and pelvic structures including the aorta, iliac arteries, and ureters. The origin is idiopathic in about 70% of the cases.

There is controversy regarding the best treatment and management for idiopathic retroperitoneal fibrosis (IRPF), and clinical strategies vary widely, from treatment with corticosteroids and immunosuppressant’s to surgery. We present the case of a patient with IRPF associated with bilateral ureteral obstruction and periaortitis, receiving treatment with tamoxifen.