Gupta Jitendra, Mohan Govind,Prabakaran L, Gupta Reena
From the past few decades, scientists consider research interest in the area of prepare of drug loaded ethyl cellulose (EC) microspheres by oil-in-water (o/w) emulsion solvent diffusion evaporation technique. Aceclofenac (ACF) is an analgesic and anti-inflammatory and diarrhoea, dyspepsia, abdominal pain, nausea, indigestion, pancreatitis, constipation the most common side effects. So the aim of the present research work was to formulation design optimization and investigation of ACF loaded EC microspheres by o/w emulsion solvent diffusion evaporation technique with different ratio of drug and ethyl cellulose as a polymer in order to achieve high entrapment efficiency and prolonged release characteristics. The prepared microspheres were characterized by scanning electron microscopy (SEM), percent yield, micrometrics properties, fourier transformer infra red spectroscopy (FTIR), percent entrapment efficiency and percent drug release characteristics. The size of microspheres formulations (F1 to F6) were in range of 10±2.1 to 51±2.7 μm, percent yield 75.32±2.21 to 95.43± 1.13%, percent drug entrapment efficiency 55.87±2.03 to 87.53±2.12% and percent drug release 58.36 ± 0.32 to 94.68 ± 0.54 % up to 12 hrs. IR and differential scanning calorimetry (DSC) study showed no interaction between drug and polymer; no degradation during microspheres preparation and stable at storage conditions. All microsphere formulations showed various drug releases kinetic but F2 formulation followed first order drug release kinetics and 94.68 ± 0.54 % drug release for prong period of time. From the study, it was investigated that free flowing and spherical microspheres of ACF could be prepared successfully by solvent diffusion evaporation technique with high entrapment efficiency and prolong release profile characteristics
