Flyer

International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 49
  • Journal CiteScore: 11.20
  • Journal Impact Factor: 8.24
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Publons
  • MIAR
  • University Grants Commission
  • Euro Pub
  • Google Scholar
  • J-Gate
  • SHERPA ROMEO
  • Secret Search Engine Labs
  • ResearchGate
  • International Committee of Medical Journal Editors (ICMJE)
Share This Page

Abstract

Enumerating Nephroprotective Potency of Ethanolic root extract of Operculina turpethum against N-Nitrosodimethylamine incited renal Carcinogenesis in Swiss Albino Mice

Sharma Veena, Singh Manu

N-nitrosodimethylamine (NDMA) is an important carcinogen frequently present in human environment and food chain. Nitrosamines such as NDMA produce oxidative stress due to generation of reactive oxygen species and alter the antioxidant defense system in the tissues. Chronic kidney disease due to a number of factors is a common and serious problem that adversely affects human health, limits longevity and increases costs to health-care systems worldwide. Oxidative stress is prevalent in kidney diseases and is considered to be an important causative mechanism. It develops from an imbalance between free radical production often increased through dysfunctional mitochondria formed with increasing age, inflammation, and reduced anti-oxidant defenses. The present study investigates the influence of ethanolic extract of Operculina turpethum roots on the kidney of NDMA intoxicated mice. The nephrotoxicity and therapeutic effect of the plant was assessed by the analysis of kidney marker enzymes, antioxidant enzymes and kidney histopathological studies. NDMA exposure produced detrimental effects on the redox status of the kidney indicated by a significant decline in the levels of protein and antioxidants such as superoxide dismutase, catalase, and glutathione and increased cholesterol, AST, ALT, ALP and lipid peroxidation. Operculina turpethum manifested chemopreventive effects by significantly restoring the enzymatic levels and reducing the nephrotoxicity in mice. Histological examination of kidney revealed patho-physiological changes in NDMA treated mice and improved plant treated renal histopathology.