Molecular Enzymology and Drug Targets

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Enzymes and Drug Targets: Current Advances and Future Perspectives

Ashutosh Mukharji*

Enzymes play pivotal roles in various cellular processes, making them attractive targets for drug development. Over the years, significant advances have been made in the identification and characterization of enzymes as potential drug targets. This review explores the current state of knowledge on enzymes as drug targets, highlighting recent developments in enzyme-targeted therapeutics and the challenges in drug discovery and development. We discuss the intricacies of enzyme inhibition, allosteric regulation, and modulatory mechanisms that influence drug efficacy and selectivity. Moreover, we delve into the emerging technologies and approaches, such as computational modeling and high-throughput screening that have revolutionized the identification of novel enzyme targets. Furthermore, we explore the potential of personalized medicine in enzyme-targeted therapies, emphasizing the importance of considering individual variability in drug response. Finally, we envision future perspectives and opportunities for exploiting enzymes as effective and tailored drug targets to address unmet medical needs and improve patient outcomes. The integration of cutting-edge research and innovative strategies promises to unlock new horizons in drug development and usher in a new era of precision medicine.


Computational modeling; personalized medicine; Precision medicine; Drug efficacy

Published Date: 2023-08-31; Received Date: 2023-08-03