T. Sivannarayana* I. John Noble Devakumar Sk. Saddam Hussain K. Phani Jithendra K. Prakash
The main objective of the present work was to develop sustained release matrix tablets of troxipide using Hydroxy propyl methyl cellulose (HPMC) Varying ratios of drug and polymer like 1:0.5,1:1, 1:1.5, 1:2, 1:2.5 and 1:3 were selected for the study. After fixing the ratio of drug and polymer for control the release of drug up to desired time. After evaluation of physical properties of tablet, the in vitro release study was performed in 0.1N HCl pH 1.2 for 2 hrs and in phosphate buffer pH 6.8 up to 12 hrs. The effects of polymer concentration were studied. Dissolution data was analyzed by Korsmeyer-Peppas power law expression and modified power law expression. It was observed that matrix tablets contained drug : polymer ratio 1:2 was successfully sustained the release of drug upto 12 hrs. Among all the formulations, release the drug which follows Zero order kinetics via, swelling, diffusion and erosion and the release profile of formulation F4 was optimized. Stability studies (40±2ºC/75±5%RH) for 3 months indicated that Troxipide was stable in the matrix tablets. The FTIR study revealed that there was no chemical interaction between drug and excipients.
