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International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 38
  • Journal CiteScore: 46.78
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Abstract

Hepatoprotective Potential of Ethanolic Leaf Extract of Plant Piper attenuatum B. Ham and Caesalpinia crista Linn

Soni Gaurav and Jeyabalan Govindasamy

Piper attenuatum B. Ham and Caesalpinia crista Linn are traditional medicinal plants in India. It has been claimed in traditional Indian system of medicine that the phytochemical constituents present in both plants having hepatoprotective activity. So, the aim of the present study was to evaluate hepatoprotective potential of ethanolic leaf extract of plant Piper attenuatum B. Ham and Caesalpinia crista Linn. Hepatoprotective potential of ethanolic leaf extract of Piper attenuatum B. Ham and Caesalpinia crista Linn were evaluated by using D-Galactosamine (400 mg/kg) induced liver toxicity model in rats. 100 mg/kg and 200 mg/kg dose selected for evaluation of hepatoprotective potential for both plants. Various biochemical parameters like AST/SGOT, ALT/SGPT, ALP, Total protein and Serum bilirubin were analyzed for different groups. Liver histopathology was also carried out for various groups. Silymarin (50 mg/kg) used as standard drug. Both the plant ethanolic extracts showed significant hepatoprotective potential. Piper attenuatum B. Ham ethanolic extract 200 mg/kg showed best hepatoprotective activity among all other groups. From the above study it may be possible that Piperine and flavonoids present in ethanolic leaf extracts of Piper attenuatum B. Ham and Caesalpinia crista Linn respectively responsible for hepatoprotective potential.