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Annals of Clinical and Laboratory Research

  • ISSN: 2386-5180
  • Journal h-index: 19
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Abstract

HIV-associated thrombocytopenia: Profiling hematological changes in the HIV infected and AIDS patients

Dr.Ajay Chandran, Dr.B.Kanagasabapathi,  Dr.C.Ramesh,  Dr.S.Nachiappan,  Dr.Tejal R.Patil,  Dr.G.Manikandan,  Dr.Adhithiya Palaniswamy,  Dr.Abhishek Singh Nayyar

Background and Aim: The first Acquired Immune Deficiency Syndrome (AIDS) case in India was detected in the year 1986. Seldom studies have been conducted correlating Cluster of Differentiation-4 cell counts (CD4 cell counts) and complete blood picture including platelet counts in the Human Immunodeficiency Virus (HIV) infected and AIDS patients in the Indian population. The present study was carried-out with the same intent to evaluate the CD4 cell counts and complete blood picture including platelet counts in the HIV infected and AIDS patients and correlate them with the sero-negative controls.

Materials and Methods: The present study was a cross-sectional, hospital-based study on the HIV infected and AIDS patients. Evaluation of complete blood picture including platelet counts was done using Sysmex XP 100- (Sysmex Corp., Hyogo, Japan), a fully automated analyzer while CD4 cell counts were evaluated using Partec Cyflow Counter- (Partec GmbH, Münster, Germany).

Statistical Analysis Used: The data was analyzed using SPSS version 15.0 (SPSS Inc., Chicago, IL, USA). Comparison of the said parameters was done using Analysis of Variance (ANOVA) and post-hoc Games-Howell test. p-value of <0.05 was considered statistically significant.

Results: The levels of hemoglobin (Hb), white cell counts (WBCs) and platelet counts showed statistically significant results (p <0.001) with the levels of Hb and platelet counts significantly decreased and levels of WBCs significantly increased in the HIV infected and AIDS groups as against the sero-negative controls.

Conclusion: Hb, WBCs and platelet counts were significantly altered in the HIV infected and AIDS groups when compared with the sero-negative controls.