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Human Papilloma Virus Related Oral Squamous Cell Carcinoma in Israel Population: Trends and Incidence

Yoav Leiser, Yasmine Ghantous, Sharon Akrish,  Imad Abu El-naaj

Aim: Our aim was to investigate the incidence of HPV related oral squamous cell carcinoma in the Israeli population.

Materials and methods: HPV typing was done by immunostaining for P16 of Tissue-Array sections, and PCR amplification from paraffin-embedded tissues [PCR Taq Mix (Promega Corporation, Israel)], on oral squamous cell carcinoma tissues spanning the period from 1996 to 2014.

Results: Immunoreactivity for P16 protein was found in 32 cases (39%), HPV16 DNA typing was found in 23 cases (28%), the HPV positive patients were significantly younger than HPV negative group, and demonstrated a higher histological differentiation.

Conclusion: A positive correlation between HPV infection and OSCC was found in the presented study; these results imply a possible involvement of HPV infection in oral carcinogenesis.