Journal of Neurology and Neuroscience

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Hypothesis on the Presence of Smooth Muscle Lysis Factor as a Marker In theDiagnosis of Neuroleptic Malignant Syndrome

Hoghoughi Nazanin1*, Maroufi Azad2, Hoghoughi Negin3

Dopamine as a neurotransmitter acts to convey messages from one cell to another and it’s secretion decrease leads to numerous diseases of motor impairment such as Parkinson disease. In the same way, the use of particular drugs that block the dopamine receptors in the brain cells results in muscle rigidity increase. One of the side effects of these drugs can be Neuroleptic Malignant Syndrome (NMS). NMS is a relatively rare but potentially fatal complication of the use of neuroleptic drugs. Measuring blood CPK (Creatine Phosphokinase ) enzyme – the result of the tension and lysis in the body of stripped muscles– can be used as one of the experimental and documentary factors to diagnose and also confirm this disease.