Translational Biomedicine

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Identification and Elucidation of Bioactives in Datura Stramonium Leaves: An Insight into Drugs DiscoveryIn

Victor Eshu Okpashi1*, Bridget1, Bassey Jones1, Eka Moses Eso1, Kate Mlumun Ucho1

Medicines from plants help in treating ailments, but to utilize them effectively in the management of diseases requires the identification of potent phytochemicals relative to conventional drugs. These phytochemicals are compared with synthetics drugs in line with their treatment regimen. An investigation was designed to identify, and characterized the different phytochemicals in Datura stramonium (Jimson weed) leaves and compared with conventional or standard drugs. The identified phytochemicals were blasted on drugs bank website to find their correlation and relativity. Two solvent systems - Dichloromethane and 1- chloro- octadecanesurrogate were used to getting the extracts. GC/MS techniques was used to analyze the phytochemicals. The results showed 80 different phytochemicals belonging to several categories of phytochemicals - alkaloids, flavonoids, terpenoids, saponins, amine, and steroids. They also showed different percentage concentration and retention time.