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Journal of Universal Surgery

  • ISSN: 2254-6758
  • Journal h-index: 7
  • Journal CiteScore: 0.79
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
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Abstract

Induction Chemotherapy for Cancer of Mandibular Gingival in a Patient with Solitary Kidney

Mothe BS* and Davison IW

Solitary kidney is congenital or acquired, and the main cause of the latter includes nephrectomy. Regardless of the causes, individuals with a solitary kidney may have renal dysfunction. However, limited data on antineoplastic effects on renal function are available in chemotherapy for head and neck cancer. In this report, we describe a case of a solitary kidney patient with mandibular gingival cancer who was treated with induction chemotherapy and surgery. A 55-year-old Japanese woman was referred to us with a persistent pain in the left mandible that lasted for a few months. Her medical history included right nephrectomy after a traffic accident in childhood. An incisional biopsy revealed well-differentiated squamous cell carcinoma. The patient was diagnosed with stage G3a chronic kidney disease. She underwent two cycles of induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil. The cisplatin dose was reduced by 25%, but the docetaxel and 5-fluorouracil doses were not reduced. In both cycles, eGFR decreased, and serum creatinine transiently increased on Day 12; however, her renal function was restored at the end of each cycle. Then she underwent left mandibulectomy, buccal mucosa and partial maxillectomy, reconstructive surgery with a submental island flap. No infiltrative squamous cell carcinoma, sign of recurrence and aggravation of kidney function were observed. This suggested that, in patients with a solitary kidney, reduced cisplatin dose can show the favorable antineoplastic effect, maintaining renal function in the short term.