BEHERA. S. M, MOHANTA. R. K, MISHRA S.K, SAHU S. K, MOHANTA L, BANERJEE M
Two series of 1- [ [3-(substituted phenyl)-5-substituted-4,5-dihydro-1HPyrazol- 1-yl] Carbonothionyl]-3-chloro-4- (Fuan-2-yl)] Azetidin-2-ones derivates were interacted through inter or intra molecular hydrogen bonding by the enzymatic keys and ADME toxicity, solubility, Drug-score and Biological activities studies, which indicated that the compounds 4(P1-P7, P11-P77) have drug likeness properties. The enzymatic keys are the target proteins or receptors of E.coli (3GI9), S.a. (4AE5), S.typhi (3FHU), cyclooxygenase (5COX) and helped for designing of the compounds 4 (P1-P7, P11-P77) for better activities by the MVD-5.0.5 software
