International Journal of Drug Development and Research

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Isolation and Characterization of Lytic Phage against Salmonella Typhimurium

Najwa Alharbi* and Sana alshaikh

Significant prevalence of antibiotic resistance in Salmonella has been observed, causing global concern that it may lead to more severe health effects. The use of bacteriophages as an alternative treatment tool for the management of bacterial infections has recently received new attention. This study aimed to identify a Salmonella typhimurium-specific phage from chicken farms. The ability of lytic phage SAL 10 to stop the growth of bacteria was verified. A series of phage analyses were conducted to verify their physical characteristics, such as temperature, pH, and host range. The phage was more stable at 37–50 °C and at pH 4–7. During the first 4 h of infection, phage SAL 10 inhibited the host bacterial growth. Following 24 h of incubation at 37 °C, phage titration was reported to be in the range of 103–108 PFU/mL in all experiments. Moreover, the morphological properties of the phage were determined using transmission electron microscopy, and the phage SAL 10 was considered to belong to the order Caudovirales and family Siphoviridae. Through the results presented in this research, SAL 10 phage can be used as a successful alternative to antibiotics.

Published Date: 2022-09-26; Received Date: 2022-08-28