International Journal of Drug Development and Research

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Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers

Vig G*

In terms of delivery to the brain, the intranasal route is a highly promising route. Nevertheless, it is one of the most challenging and complicated routes. As a outcome, researchers are constantly looking for novel drug delivery vehicles like polymeric and lipid nanoparticles that are likely to improve the bioavailability of the drugs that are given to the brain.A certain number of publications from various databases and the literature were selected for this study.In order to investigate the published studies and demonstrate the superiority of nanocarriers in increasing the bioavailability of various drugs in the brain, meta-analyses employing two distinct algorithms (DerSimonian–Laird and inverse variance) were carried out.In addition, lipid nanosystems and polymeric nanosystems were quantitatively compared. After normalization, the meta-analysis used the important pharmacokinetic parameter known as the area under the curve (AUC) from in vivo animal studies as the "effect."Plots of forest were created. Closure and key findings:After comparing it to more conventional preparations like solutions and suspensions, the metaanalysis found that the AUC increased.Most importantly, it was demonstrated that lipid nanoparticles were significantly superior to polymeric counterparts.


Nasal; Nanocarriers; Polymeric; Lipid; Systematic; Meta-Analysis

Published Date: 2022-10-28; Received Date: 2022-09-26