Journal of Biomedical Sciences

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Micro RNAs' roles in coronary artery disease and revascularization

Graciela Carlos*

The vascular wall's chronic inflammatory response is commonly regarded as atherosclerosis, and its complications contribute significantly to patient mortality. Patients with atherosclerotic disease frequently undergo an angioplasty with stent replacement. However, angioplasty patients typically experience a high rate of restenosis. New signalling molecules that regulate the progression of atherosclerosis and restenosis have continuously been discovered, despite the well-established pathophysiological mechanisms that underlie these conditions. A new class of gene regulators known as microRNAs (miRs) function through translational inhibition or activation and transcriptional degradation

More than 30% of the cell's genes can be directly controlled by miRs. As a result, it is accepted that miRs play a crucial role in normal development, physiology, and pathogenesis. Diverse vascular diseases have been linked to variations in miR expression profiles. It has been discovered that miRs regulate a wide range of vascular cell functions, including cell differentiation, contraction, migration, proliferation, and inflammation. These functions are also involved in angiogenesis, the formation of noontime, and the lipid metabolism that underlies a variety of vascular diseases. Atherosclerosis and restenosis are characterized by the regulation of vascular cell function by miRs, which are the subject of this review. Clinical diagnostic and therapeutic approaches for vascular diseases caused by atherosclerosis and restenosis will likely benefit from these discoveries

Keywords Cardiovascular; Syndromes; Surgical treatments Cardiovascular; Syndromes; Surgical treatments

Published Date: 2022-11-30; Received Date: 2022-11-01