Translational Biomedicine

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miRNA as a Potential source for combating biotic & abiotic stress in plants and Cancer treatment in humans

Sharma D*, Verma M, Khamrai A, Nair A and Sanjay S

MicroRNA belongs to the class of endogenous non coding RNAs, they modify the expression of their target gene in both plants and animals. In this review, the potential of miRNAs is discussed to help the plants resist biotic and abiotic stress. We will also bring insight the application of miRNAs a potential tool to diagnose various level of cancer metastasis and an effective method for cancer treatment. These miRNAs are target specific and are likely to regulate responses like plantpathogen interaction, signaling pathways, metabolism, etc. in the plants. While their uneven expression and target regulation during the cancer makes them an effective source to work as biomarker. There is research where miRNAs were used along with nanoparticles to treat cancer and were found to be useful. This study will provide us with some evidence to demonstrate the molecular role of miRNA in plant to response against various stresses and differential expression of miRNA with their target gene regulation during cancer metastasis