Archives of Medicine

  • ISSN: 1989-5216
  • Journal h-index: 17
  • Journal CiteScore: 4.25
  • Journal Impact Factor: 3.58
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Proquest Summons
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • Google Scholar
  • Secret Search Engine Labs
Share This Page


Neurophybromatosis type 1 and vascular risk: outlining a new hypothesis

pez Castro J

Background: The neurofibromatosis of type 1 (Von Recklinghausen disease) -NF1- belongs to the genetic disorder group known as phakomatosis. Its inheritance pattern is dominant autosomal with variable penetrance. It is produced by the mutation of the gene NF1 of the chromosome 17q (tumour supresor gene which encodes a protein -neurofibromine- which modules the transduction of signals through the guanosin triphosphatase path -GTPase-). It’s characterized by the presence of benign tumors from the peripheral nerves which are nominated neurophybromas (they are compounded by the proliferation of Schwann cells and phybroblasts), pigmented skin lesions (“café au lait spots“), freckles on unexposed areas like the armpits, iris hamartomal (Lisch’s nodules) and seudoarthrosis of the tibia [1,2]. It has been described that the patients with NF1 can present neurovascular abnormalities which tend to brain ischemia [3], although this uncommon association is not well characterized.