International Journal of Drug Development and Research

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On The Factors That Affect Concentration Variations in A Veterinary Drug Using Backward Stepwise Regression Analysis

Omar Bataineh*, Musaab Abu-Fares, Murad Al-Jdayeh

This work investigates the case of controlling the variability in the concentration of Citrus oil, a key ingredient used in the manufacturing of an oral solution veterinary drug produced by the Arab Company for Manufacturing Veterinary and Agricultural Products Ltd. (ARVET) in Ramtha, Jordan. The problem occurs as the drug is produced in large batches that comprise a number of ingredients and mixed together. Factors such as batch size, mixing time, and pH of the pure solution are thought to have an effect on homogeneity of the mixture and thus concentration variability in the final product. Although numerous ingredients are used in the drug of interest such as Bromhexine HCl, Eucalyptus oil, Thymol and Camphor, the focus in this study is restricted to the Citrus oil ingredient as a first-stage investigation. The study will employ the power of statistical techniques such as backward stepwise regression (BSR) analysis to identify the most influential factors. Besides, the best setting of the confirmed influential factors will then be determined