Larry H Bernstein
This is a review of a recent work from the laboratory of Mark E. Anderson and associates at the University of Iowa. This laboratory has covered the role of calcium calmodulin II (CaMKII) in calcium signaling and myocardiocyte contraction, as well as signaling in smooth muscle, skeletal muscle, and nerve transmission. There are tissue specific mechanisms of action, partly related to the ryanogen receptor (RyR), and also related to tissue specific isoenzymes of CaMKII. Much ground has been traversed in exploring these mechanisms. This includes the recent discovery of hormone triggering by the release from vesicles at the nerve muscle junction, and much remains open to investigation.