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Annals of Clinical and Laboratory Research

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Abstract

Pertinence of the Immunofixation Prescription in Heterogeneity Restrictions of the Gammaglobulin Zone

Soufiane Nader*, Adam Bentahila, Mehdi Ztoute, Abdelhamid Zrara and Amina Benouda

Monoclonal gammopathies are regularly materialized on an EPP by a narrow peak in the gamma zone. Sometimes this expression is expressed by a deformation which affects the Gaussian aspect of the curve expressing these gamma globulins it is called restriction of the heterogeneity of the gamma globulins, this can mask a monoclonal gammopathy. Our objective is to study the relevance of prescribing immunofixation in this circumstance. This is a retrospective study of all serum protein electrophoresis completed by immunofixation. 16 patients had restriction of gammaglobulin heterogeneity. Immunofixation revealed that 12 cases (75%) out of 16 had indeed monoclonal gammopathy. It can thus be concluded that the restrictions of gamma heterogeneity in elderly patients should raise the suspicion of monoclonal gammopathies.

Received Date: 2022-04-27