Monoclonal gammopathies are regularly materialized on an EPP by a narrow peak in the gamma zone. Sometimes this expression is expressed by a deformation which affects the Gaussian aspect of the curve expressing these gamma globulins it is called restriction of the heterogeneity of the gamma globulins, this can mask a monoclonal gammopathy. Our objective is to study the relevance of prescribing immunofixation in this circumstance. This is a retrospective study of all serum protein electrophoresis completed by immunofixation. 16 patients had restriction of gammaglobulin heterogeneity. Immunofixation revealed that 12 cases (75%) out of 16 had indeed monoclonal gammopathy. It can thus be concluded that the restrictions of gamma heterogeneity in elderly patients should raise the suspicion of monoclonal gammopathies.
Received Date: 2022-04-27