International Journal of Drug Development and Research

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Preparation and evaluation of Novel Vaginal Pessaries of Lactobacilli

Vinita Kale, Mahesh Patil, Shobha Yadav

The objective of this study was to develop Multifunctional vaginal Pessary containing Probiotic and Prebiotic. The novel Multifunctional Bilayer Pessary with Probiotic and Prebiotic in separate layers was developed using blends of PEGs as base. Solubility of Blend of PEG used for preparation of Prebiotic layer was greater than that used for Probiotic layer. That makes Prebiotic to release first and create favorable condition for growth of Probiotic that would be released subsequently. Prepared Multifunctional Bilayer Pessaries were evaluated for viability and stability. Also, plain and hallow type Pessary containing Probiotic alone were prepared and comparatively evaluated with Multifunctional Bilayer Pessary. The effect of Prebiotic on growth of Probiotic was studied for Bilayer Pessaries and results indicated that growth rate of Probiotic increases in presence of Prebiotic. The selected lactobacillus sp. was tested for membrane adherence and for production of antimicrobial substances. Result showed the ability of selected lactobacillus sp. for membrane adherence and production of antimicrobial substances like bacteriocins. The stability studies demonstrated that the hollow-type and Bilayer Pessaries with mixed PEGs as the base are stable after storage at 2-8°C over the period of 4 weeks.