David Azako*, Cristian Matanda, Serge Mpwate, Vincent Mbatu, Rive Lukuaku, Julia Mbwamulungu, Fanfan Nzeza, Gabriela Kikwedi, Teddy Mukendi, Fabrice Bokambandjaa and Bienvenu Lebwaze
Anogenital squamous cell carcinomas are mostly HPV- induced but in the Democratic Republic of Congo (DRC) there is no HPV vaccination program or HPV screening program. The aim of this study was to determine the frequency of HPV-induced anogenital squamous cell carcinoma and the mutation of p53. In this descriptive cross-sectional study, performed immunostaining at p16, p53 and Ki-67 on 30 tissues of 10% formalin-fixed anogenital squamous cell carcinoma. Strong and diffuse expression of p16 was noted in 93% of cases; 66.6% of cases that had shown strong and diffuse expression of p16 and the 2 cases that had not shown p16 expression were not marked by the anti-p53 antibody; 8 cases that had shown strong and diffuse expression of p16 showed an expression of p53 less than 10%; 90% of cases that showed strong and diffuse expression of p16 showed a high expression of Ki-67, i.e. 40% to 90%; the 2 cases that showed no expression of p16 showed an expression of Ki-67 less than 10%; finally, a case that showed strong and diffuse expression of p16 showed no expression of Ki-67. In this study, the vast majority of male anogenital squamous cell carcinoma are HPV-induced, did not note any cases of mutation of Tp53. The introduction of the HPV vaccine and the national program for the early screening of HPV-associated lesions is an emergency in the DRC.
Published Date: 2024-08-22; Received Date: 2024-07-22
