The Comparative Evaluation of S100B Protein, Glasgow Coma Scale and Neuro-Depiction over Head Injuries in Childhood
Feidantsis T, Patoulias I, Spyridakis I, Zafeiriou D, Adamopoulos V, Arvaniti M and Sfoungaris D
Aim: The evaluation of the S100B alterations as a prognostic biomarker of Head Injuries (HI) in childhood.
Materials and methods: In this study 74 children (45 boys and 29 girls), 3-14 years old (Average: 7.86 years old) from 1/2017 until 9/2017 involved. 64/74 patients with clear HI and 10/74 witnesses, while no one needed mechanical breathing support or hospitalization in the Emergency Department (ED). Based on the severity of the clinical manifestations they were classified into 4 groups. The determination of the S100B with ECLIA method was carried out in 3, 12, 24 and 48 hours after the HI with cut-off rate the 0.191 μg/L. 64/74 patients were submitted to neuroimaging via head and brain CTs, 6-8 hours after the injury.
Results: Though the statistical processing of the results it was ascertained 100% sensitivity, 96.16% specialization, 85.71 positive prognostic value and 100% negative prognostic value of S100B.
Conclusions: The early determination of S100B during the initial evaluation of a child with HI can constitute a diagnostic test for the possibility of a coexisting intracranial complication; S100B if applied on a regular basis, can constitute as a detection testing in children who are submitted to the ED due to HI; Calculation of S100B before discharged from the hospital, could be served as an indicator of the improving clinical condition.
