Background: Lung cancer is the most common primary site of brain metastases. Patients with a single brain metastasis from non-small cell lung cancer (NSCLC) have the potential for long term survival. Case report: A 39-year-old man presented stage IIIB (cT2N3M0) NSCLC. He underwent concurrent chemoradiotherapy. Follow-up chest CT and PET-CT showed complete tumor remission. The patient had headache and visual symptom 18 months after completion of treatment. The brain MRI showed metastatic brain mass. The size of single mass was 6.6 cm. He refused surgical procedure for brain lesion. He received radiation therapy. Total dose to PTV was 30 Gy in 5 fractions. The radiation therapy was well tolerated. Partial response of brain lesion was achieved and remained stable for 10 months until bone metastasis was found. Conclusions: Fractionated stereotactic radiotherapy (FSRT) in the current study could achieve good local tumor control and prevent neurological symptoms from worsening.