Defne Kalayci, Suat Konuk, Tuncer Tug
Background: Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation. In this study, we aimed to determine the serum levels of omentin in asthma patients and its relation to atopy.
Methods: A total of 47 asthmatic patients and 39 healthy adults were involved. Patients with chronic airway disease or chronic systemic disease were not included in the study. In addition to the pateients’ routine biochemical tests, the serum omentin levels were determined by the ELISA method by means of the Human Elisa Kit. The Statistical evaluation of the study was performed using the SPSS 16.0 package program and p<0.05 values were considered significant.
Findings: Serum omentin levels of asthmatic patients (107.0 ± 23.7 pg /ml) were higher than those of the control group (84.0 ± 44.2) (p=0.028). A statistically significant difference was found between the serum omentin levels of the groups according to the severity of asthma (p=0.008). Serum omentin levels were significantly higher only in the mild persistent asthma group compared to the moderate asthma group (p=0.021). The serum omentin levels in the non-smokers were significantly higher in the control group than the smokers (p=0.005). As in the asthmatic patients, also in the control group, the serum omentin levels of the women were significantly higher than the levels in men (p<0.001). In asthma group, there was a negative correlation between omentin level and the body mass index in men (p=0.040, r=-0.599). In the control group, the same negative correlation was detected between omentin level and the body mass index in women (p=0.008, r=-0.484).
Conclusion: In this study, the serum omentum levels were found to increase in asthmatic patients. In addition, it has been shown that omentum levels are higher in women than men.