International Journal of Drug Development and Research

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Simultaneous Estimation of Aliskiren and Amlodipine in Tablet Dosage form by UV Spectroscopy

Das Paramita, Patel Sandip, P.P. Radhika, Subramanyam E.V.S, A. Sharbaraya

Two simple, sensitive, rapid and accurate analytical methods have been developed for the simultaneous of ALISKIREN and AMLODIPINE in marketed formulation of pharmaceutical dosage forms. The Q-analysis based on measurement of absorptivity at 279nm and 289nm (as an isoabsorptive point). The second method developed and validated of simultaneous equation using 279/361nm. ALISKIREN and AMLODIPINE at their respective λmax 279nm and 361nm and at iso absorptive point 289nm show linearity in a concentration range of 20-100μg/ml and 5- 25μg/ml.Recovery studies range from 99.51% for Aliskiren and 99.51% for Amlodipine in case of simultaneous equation method Aliskiren was 100.10% and Amlodipine was 100.47%.