In children under the age of five, rotavirus infections are the most common cause of severe, dehydrating gastroenteritis. Over a decade after the worldwide introduction of rotavirus vaccinations, more than 200,000 people die annually from rotavirus infections, most of who occur in low-income nations. The enteric nervous system is activated, intestinal secretion is stimulated by rotavirus non-structural protein 4, and absorptive enterocytes are destroyed, resulting in malabsorption, when rotavirus infects enterocytes. Rotavirus infections can also cause viraemia and antigenaemia, both of which are linked to more severe symptoms of acute gastroenteritis. Rotavirus can also replicate in systemic sites, but this is rare. Reinfections with rotavirus are normal over the course of life, albeit the illness seriousness is diminished with rehash diseases. Although rotavirus-specific immunoglobulin a plays a role in both aspects, the immune correlates of recovery from infection and protection from rotavirus reinfection are poorly understood. Although the administration of antiviral and anti-emetic medications may be required in some instances, the prevention and treatment of dehydration are the primary focuses of rotavirus infection management.
Published Date: 2022-12-30; Received Date: 2022-12-02
