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International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 51
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Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF 1,3,4-OXADIAZOLE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AND ANTIFUNGAL AGENTS

Palak K. Parikh, Hiren M. Marvaniya and Prof. Dr. Dhrubo Jyoti Sen

1,3,4 oxadiazole derivatives are the heterocyclic compounds with very important biological activities such as anti-inflammatory, antimicrobial, antifungal, antiviral, analgesic, antimycobacterial, antidepressant and antiamoebic. 1, 3, 4 oxadiazole was synthesized by condensation reaction between 2- hydroxybenzohydrazine and carbon disulfide. This derivative on treatment with different aromatic halides produced the desired final products. The in-vitro antibacterial activity of synthesized compound was tested against Gram-positive and Gram-negative microorganisms (Staphylococcus aureus ATCC 9144, Bacillus subtilis ATCC 6633, Pseudomonas aeruginosa MTCC No. 1688, Gram negative: Escherichia coli ATCC 25922) by filter paper disc method. The in-vitro antifungal activity was tested against Candida albicans by filter paper disc method. All the compounds showed good activity against all cultures.