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Synthesis of New Barbiturate Esters as Intravenous Anesthetics: A new Dimension of Anesthesia Route

Md. Ehsanul Huq, Abu Mohammad Azmal Morshed, W. E. Sneader

The aim of this research described here to meet these requirements of rapid metabolism in the particular case of anesthetic barbiturates. In this communication six barbiturate esters were synthesized, their anesthetic activity was carried out in mice and compared their potency, duration of action and rate of recovery with pentobarbitone and thiopentone. The two compounds showed markedly faster recovery than thiopentone, the rate of onset was rapid and the CNS excitation prior to anesthesia as seen with pentobarbitone was clearly absent.