Translational Biomedicine

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Targeted weight reduction using Sibutramine.

Stritecka Hana , Hlubik Pavel , Hlubik Jan

Obesity is a serious chronic disease resulting from positive energy balance. Obesity is also an independent risk factor for the developmentof non-communicable widespread disorders. The endpoint of the trial was a targeted reduction of excessive body weight in 99individuals with BMI over 30 or 27 kg/m2 respectively. Three-month weight reduction therapy was based on the restriction of energyintake and pharmacotherapy by Sibutramine hydrochloride monohydrate (Sibutramine) 10 mg/person/day. Results: three-monthtargeted therapy resulted in statistically significant decrease of BMI, body weight, body fat and waist circumference. The reductionimproved lipid profile and resulted in the decrease of systolic and diastolic blood pressure. Heart rate increased only insignificantly.Targeted reduction of excessive body weight using Sibutramine pharmacotherapy had a positive effect on anthropometric and biochemicalcharacteristics without any adverse effect of nutrition in participating individuals.