Molecular Enzymology and Drug Targets

  • Journal h-index: 5
  • Journal CiteScore: 0.46
  • Journal Impact Factor: 0.45
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • China National Knowledge Infrastructure (CNKI)
  • Publons
  • Google Scholar
  • Secret Search Engine Labs
  • Zenodo
Share This Page


Tetracyclines and macrolides' short-term effects on methanogenic activity specifically and swine biodegradability

Shweta Ekka*

Few research have looked at kinetic models that relate to how antibiotics affect acetoclastic methanogenesis and the biodegradability of swine wastewater, but these models can be helpful for improving and correctly operating anaerobic systems. Numerous researchers have assessed how well antibiotics work alone or, rarely, in combination to block this key pathway for the production of methane. In order to assess their inhibitory effects, the two tetracyclines oxytetracycline and tetracycline as well as the macrolide tylosin were administered singly as well as in combination. While the lower one was on methane production at the assays with swine wastewater showed that OTC and TCN had the highest inhibition on BD at 45 days, short-term inhibition assays are useful to evaluate the antibiotics impact detected on swine wastewater specific methanogenic activity and biodegradability at different concentrations of antibiotics. Respectively as anticipated, the highest concentrations of OTC and MIX caused the greatest reduction in methane generation in the assays, while TYL had no effect on methane production in any of the assays.


Antibiotics for veterinary uses; Acetoclastic methanogenesis; Half-maximal inhibitory concentration; Swine wastewater; Synergistic effect; Uncompetitive inhibition

Published Date: 2023-05-28; Received Date: 2023-04-03