Andi Munisa, Wasmen Manalu, Tutik Wresdiyati, Nastiti Kusumorini
The study was conducted to observe the effect of clove leaf methanol extract on the profile of superoxide dismutase (SOD) and malondialdehyde (MDA) in the liver of rabbits under hypercholesterolemia. Nine male New Zealand rabbits were used for this study. They were divided into three groups i.e (1) negative control group, (2) Positive control group (hypercholesterolemic) was fed with diet containing 1% cholesterol for 50 days, and (3) the group was given clove leaf extract and 1% cholesterol for 50 days. The hypercholesterolemic condition decreased SOD activity and Cu, Zn-SOD level, otherwise the increasing of MDA level occurred on the liver of the rabbits in the positive control group compared to negative control group. On the other hand, the third group showed the increase of SOD activity and Cu, Zn-SOD level with clove leaf methanol extract. The best results were obtained in the rabbits treated with clove methanol extract simultaneously for 50 days.