Flyer

Journal of Neurology and Neuroscience

  • ISSN: 2171-6625
  • Journal h-index: 15
  • Journal CiteScore: 2.13
  • Journal Impact Factor: 1.45
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Indexed In
  • Open J Gate
  • Genamics JournalSeek
  • The Global Impact Factor (GIF)
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Proquest Summons
  • Scientific Journal Impact Factor (SJIF)
  • Euro Pub
  • Google Scholar
  • Secret Search Engine Labs
Share This Page

Abstract

The Potential Therapeutic Value of BDNF-TrkB Pathway in COVID-19 Associated Stroke

Sanketh Andhavarapu, Joseph Bryant, Volodymr Gerzanich, Marc J Simard and Tapas Kumar Makar

Infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared the coronavirus disease 2019 (COVID-19) pandemic by the World Health Organization (WHO) on March 11th, 2020. While most symptoms are those associated with the respiratory system, common symptoms also involve the nervous system. Stroke is a common complication of COVID-19, and it has been stated that future research should investigate the underlying mechanisms of COVID-19 associated thrombosis in order to develop preventative strategies for complications such as ischemic stroke. This is likely because SARS-CoV-2 binds to the angiotensin converting enzyme 2 (ACE2) receptor, and decreased activity of ACE2 promotes risk of stroke by causing an imbalance of the renin-angiotensin system. ACE2 is an enzyme that plays a role in the release of neurotrophic factors such as brain derived neurotrophic factor (BDNF), which plays a critical role in neurogenesis, cognitive function, and neurodevelopment. Earlier, it has been reported that the BDNF-TrkB system is neuroprotective during stroke. BDNF-TrkB signalling acts as a mediator of the renin-angiotensin system in the brain, and this regulatory effect may be disturbed during COVID-19 infection. This review consolidates the existing literature on the extensive role of the renin-angiotensin system and angiogenesis in COVID-19 and stroke with a focus on the BDNF-TrkB pathway. We hypothesize that the risk for stroke is higher in COVID-19 patients due to inhibition of BDNF that results from the downregulation of the ACE2 receptor during infection of SARS-CoV-2. In parallel, this review suggests that BDNF therapy may reduce the risk of stroke events and/or aid post-stroke recovery in COVID-19 patients.