Alzheimer's disease is one of the most common neurodegenerative disorders that affects millions globally. It is characterized by loss of neurons, neurofibrillary tangles, and beta-amyloid accumulation, however, the mechanism behind these pathological features is still unclear. Recently, increasing evidence demonstrates the role of the meningeal lymphatic system (MLS) in cerebrospinal fluid (CSF) transportation, beta-amyloid clearance, and neuroinflammation. Thus, MLS may be considered a potential therapeutic target for neurodegenerative diseases. Here, we discuss the multiple functions of the meningeal lymphatic system and its potential role in the progression of Alzheimer's disease.
Published Date: 2022-05-31; Received Date: 2022-04-13